Good news was hard to find Monday as San Francisco 49ers head coach Kyle Shanahan reviewed the list of his players dealing with a variety of injuries.

The San Francisco 49ers have been struggling with injuries all season, and it finally caught up with them. On Sunday, they lost 26-15 to the Houston Texans.

NFL Week 9 odds, picks, predictions, TV channel, streaming information for the Sunday football game between San Francisco 49ers and New York Giants.

The Houston Texans' quarterback-head coach tandem sounded off after a massive win vs. the San Francisco 49ers.

The 49ers offense sabotaged the defense and the defense failed to set up the offense in one-sided loss to Texans.

Houston Texans cornerback Kamari Lassiter, right, intercepts a pass intended for San Francisco 49ers wide receiver Jauan Jennings during the second half of an NFL football game Sunday, Oct. 26, 2025, in Houston. Sunday’s loss to the Texans was the latest chapter in a season to forget for 49ers receiver Jauan Jennings.

We always knew the San Franciscio 49ers 2025 rookie class going to have a big say in what the outcome of the season would be. While the team got off to a hot start, and the rookie class has had some highs, the lows of the class also have shown in what could be a sign that the 49ers season does not have a high ceiling.

The San Francisco 49ers were hoping their rookies would be ready to pick up the slack after injuries to so many veteran players. Those hopes were dashed in Houston.