One of the biggest preseason delights for Chicago has been defensive end Austin Booker, who has four sacks already. After picking up his fourth sack of the preseason in this game against Buffalo, Booker met with the medical staff and then was later ruled out with a knee injury.

The Bills not only lost to the Bears to drop to an 0-2 record in the preseason, but they lost 38-0 as it seemed like none of the three phases showed up over the course of the game. The Bills fell behind 7-0 after the first quarter,

The Chicago Bears blew out the Buffalo Bills in Week 2 of the 2025 preseason. Here are the big winners and losers from the game.