13 NFL Picks Predictions

NFL Week 1 big underdog picks of week

Commanders vs Eagles Prediction, Picks & Odds: NFL Week 1

The Washington Commanders and Philadelphia Eagles start their 2026 seasons with a classic NFC East tilt at Lincoln Financial Field on Sunday, Sept. 13, and the Eagles are 5.5-point home favorites ahead of the 4:25 ET p.m. kickoff.

· 23m

Packers vs. Vikings predictions, odds, time: 2026 NFL Week 1 picks by proven model

· 15h

New York Jets at Tennessee Titans NFL Prediction, Picks & Odds for Sept. 13, 2026

· 3h

Week 1 NFL odds, picks, predictions: Computer model backs Eagles and Jaguars

The NFL never shies away from loading up the opening week with must-see matchups, and the Week 1 NFL schedule is no different.

· 20h

Picks for every Week 1 NFL game

· 1d

Which NFL Week 1 game—besides the Lions—are you most excited about?

· 1d

Best NFL Betting Promos for Week 1: Sportsbook Promos, Bonus Codes for Vikings-Packers, Giants-Cowboys

The Week 1 NFL schedule is loaded with playoff rematches and divisional rivalry games, including Texans vs. Bills at 1 p.m. ET, Vikings vs. Packers and Eagles vs. Commanders at 4:25 p.m. ET.

· 1d

How to bet on 2026 NFL Week 1: Betting guide, odds, game previews, trends, schedule, promo codes, more offers

· 1d

How to bet on NFL Week 1: Where to bet, best betting sites, apps, promo codes for 49ers vs. Rams in Australia

Doc's Sports

Cleveland Browns vs Jacksonville Jaguars Prediction, 9/13/2026 NFL Picks, Best Bets & Odds Week 1

The Jacksonville Jaguars (13-4 last season) will go up against the Cleveland Browns (5-12 last year) at EverBank Stadium on Sunday. Jacksonville opens this game as 8-point favorites from Vegas oddsmakers.

Sporting News on MSN

NFL picks, predictions against the spread week 1: Giants stun Cowboys, Chiefs edge Broncos

In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.