2020 NFL Week 2 Preview

NFL, Bills and Lions

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SportsLine · 14h

NFL Week 2 score predictions: Expert reveals game picks for every Week 2 matchup

SportsLine expert Eric Cohen reveals his NFL score predictions for all 16 games in Week 2 of the 2026 NFL season

LIVE

· 5h

Lions vs Bills live updates, NFL Week 2 game score, highlights

· 5h

Thursday Night Football live updates: Bills vs Lions score, highlights, TV channel

· 8h

What channel is Bills-Lions Thursday Night Football game on tonight live?

The 2026 NFL season slate of Thursday Night Football continues in Week 2 with the Buffalo Bills hosting the Detroit Lions at Highmark Stadium on Prime.

· 10h

Thursday Night Football live updates: Bills vs Lions start time, TV channel tonight

· 11h

What channel is Lions vs Bills game on tonight? Thursday Night Football time, TV schedule

· 17h

Thursday Night Football predictions, picks, odds for Bills vs Lions

The Arizona Republic is predicting a 30-24 win for the Bills over the Lions in the NFL Week 2 Thursday Night Football game.

· 18h

What channel is Thursday Night Football on? How to watch Lions-Bills

· 20h

Who's playing on Thursday Night Football tonight? Lions vs Bills

16hon MSN

Bills vs. Lions predictions, odds, spread, time: Week 2 Thursday Night Football picks from advanced model

The SportsLine projection model has revealed its Detroit vs. Buffalo picks for NFL Week 2 on Thursday, Sept. 17 as Highmark Stadium hosts its first regular-season game

RotoWire

NFL Staff Picks: Week 2 Winners & Predictions

NFL expert picks for Week 2 with staff predictions and against-the-spread winners to help guide your betting picks and pools.