The Tampa Bay Buccaneers return home to face off against the San Francisco 49ers in Week 6. The 49ers got a positive injury update on Brock Purdy on Thursday mo

Tampa Bay is a 3-point favorite in the latest 49ers vs. Buccaneers odds from SportsLine consensus, while the over/under for total points scored is 47.5. The Buccaneers are -161 money line favorites (risk $161 to win $100),

The 49ers are off to a 4-1 start and the banged up team expects an important addition in time for its Week 6 matchup with the Bucs.

The Buccaneers also played on the West Coast. They did the 49ers a favor and knocked off the Seahawks in Seattle, 38-35. Baker Mayfield completed 29 of 33 passes for 379 yards and two touchdowns. Rookie Emeka Egbuka caught seven of those passes for 163 yards.

Baker Mayfield has been outstanding this season, but our expert NFL predictions don't expect him to have a huge passing day against a good 49ers pass defense.

The Tampa Bay Buccaneers (4-1) have 11 players listed on their injury report as they prepare to meet the San Francisco 49ers (4-1) on Sunday, Oct. 12 at Raymond James Stadium, with the opening kick scheduled for 4:25 p.m. ET. Game time: 4:25 p.m. ET

Preview the Week 6 matchup between the Tampa Bay Buccaneers and San Francisco 49ers with predictions, odds, over/under, spread, betting lines and more.

Preview the San Francisco 49ers' NFL week 6 matchup with the Buccaneers, including betting odds, tips, trends, and game information.

Broadcast and streaming information for the San Francisco 49ers Week 6 matchup against the Tampa Bay Buccaneers at Raymond James Stadium.

Connor Colby has been the 49ers' biggest issue in pass protection, but he has been passable as a run blocker. Now, he gets the Buccaneers defense, which is the best in the NFL at defending the run.