March 1, 2012 — The anti-inflammatory drug celecoxib (Celebrex, Pfizer) can be used to significantly reduce hand-foot syndrome (HFS), the most common adverse effect of an increasingly popular ...

Capecitabine is an oral fluoropyrimidine prodrug widely employed in the management of colorectal, breast and gastric malignancies. While generally more convenient than intravenous 5-fluorouracil, it ...

Hand-foot syndrome (HFS) is a dose-limiting side effect of capecitabine. Celecoxib prevents HFS by inhibiting cyclooxygenase-2 (COX-2) that is upregulated because of the underlying associated ...

Oral vitamin B12 supplements may offer an additional way to prevent hand-foot syndrome, a common side effect of chemotherapy with capecitabine, a clinical trial suggested. The phase 3 trial, conducted ...

Chemotherapy is often an effective way to treat gallbladder cancer, prevent it from spreading further, and improve overall survival. Capecitabine is a chemotherapy drug often used for this purpose.

FDA labeling now recommends DPYD variant testing before initiating capecitabine or 5-FU, except when immediate treatment is clinically necessary. Complete DPD deficiency markedly impairs 5-FU ...

Trastuzumab-Pertuzumab Plus Eribulin or Taxane as First-Line Chemotherapy for Human Epidermal Growth Factor 2–Positive Locally Advanced/Metastatic Breast Cancer: The Randomized Noninferiority Phase ...