NFL Week 1 DFS the DraftKings main slate has been set since July. Whether you play GPP or Cash adjust your lineups accordingly.

NFL DFS picks for Week 1 featuring top plays, value targets and lineup strategy to help you build winning rosters on DFS for Yahoo.

Tampa Bay gave up 13 quarterback games of at least 15. 4 fantasy points in 2025, so the matchup doesn’t scare me.

SportsLine's team of Vegas experts and its proven model and experts to get you ready for Week 1 NFL betting

The Cowboys have a new-look defense with new defensive coordinator Christian Parker and first-round pick Caleb Downs. The John Harbaugh era begins in New York. Dak Prescott is 14-3 S/U against the Giants – and Dallas has won nine of the last 10 meetings.

Every week, the first step of your DFS homework should be to examine the opening Vegas odds on all the NFL games for that week. Through some fairly simple algebra, it is easy to derive a spreadsheet that predicts team totals for every game, thereby allowing you to develop a rudimentary game script to help narrow down your decisions for the week.