The Detroit Lions will play their first game on the road for the 2026 season tonight against the Buffalo Bills at Highmark Stadium. Looking to watch the game from home? We’ve got all the information you’ll need to be ready for kickoff.

There is a Lions simulcast in Detroit and a Bills simulcast in Buffalo, despite the Week 2 NFL game being on "Thursday Night Football" and streaming exclusively on Amazon's Prime Video.

Lions defensive back Avonte Maddox was ruled out Thursday night at Buffalo after injuring his foot in the second quarter.