The Detroit Lions are visiting the Buffalo Bills at the new Highmark Stadium on Thursday Night Football. Follow the score and live updates.

The Detroit Lions will play their first game on the road for the 2026 season tonight against the Buffalo Bills at Highmark Stadium. Looking to watch the game from home? We’ve got all the information you’ll need to be ready for kickoff.

The Buffalo Bills host the Detroit Lions in Week 2 of the 2026 NFL season on Thursday. There are several ways fans can watch and stream Thursday's game. Detroit went up 21-0 midway through the third quarter of Sunday's game against the New Orleans Saints after forcing turnovers on consecutive drives, and had to escape with a 31-30 overtime win .

The Detroit Lions announced a trio of game day roster moves prior to tonight's contest at the Buffalo Bills.

On the other side of inactives, Bills defensive tackle Ed Oliver suffered an injury in pre-game warmups and is out for Week 2.

Down Blake Miller and Christian Mahogany vs. The Bills, the Detroit Lions have elevated a couple of offensive linemen from their practice squad.

With Blake Miller ruled out, Larry Borom is likely to start at right tackle and could determine how much Detroit must alter its offense against Buffalo.

Check out the best pick 'em plays, optimal lineups, and promos for DraftKings, Betr, Underdog, and more for Bills vs. Lions Thursday.