It's ACC champion Duke against American champ Tulane in a big moment for both programs and their respective conferences. Here's the CFN preview and prediction.

It's Duke football vs. Tulane in Week 1 of the 2026 college football season. Here are some things to watch and a prediction.

A comprehensive preview, including betting odds and predictions, for the NCAAF game between the Tulane Green Wave and Duke Blue Devils on Sept. 5, 2026.

The Blue Devils and Green Wave will kick off the 2026 season on Saturday inside Wallace Wade Stadium. What will decide the game for Duke? We examined the match-up and came up with the formula for going 1-0.

The Tulane Green Wave (11-3 last season) are on their way to Wallace Wade Stadium on Saturday, September 5, 2026 where they will take on the Duke Blue Devils (9-5 last year). Duke opens this matchup as 9.5-point favorites from oddsmakers. The betting total is set at 50.5.

Week one is finally here, so we're making our picks for Saturday's game in Durham, NC.