Interactions among loci or between genes and environmental factors make a substantial contribution to variation in complex traits such as disease susceptibility. Nonetheless, many studies that attempt ...

Epistasis arises when alleles at one locus modify the phenotypic expression of alleles at another, generating non-additive contributions to trait variation. In natural populations, genetic variance ...

Euan Ashley's lab explores the intricate interactions of gene variants. Tiny "typos," or genetic mutations, can sneak into segments of DNA. Many of these are harmless, but some can cause health ...