In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.

All scheduled NFL games played in week 18 of the 2026 season on ESPN. Includes game times, TV listings and ticket information.

For the first time ever, the NFL will host a regular-season game in Australia, and it will be the Los Angeles Rams taking on the San Francisco 49ers for a crucial NFC West matchup in Week 1. Both of these divisional rivals made the postseason a year ago and had their seasons ended by a third NFC West team,