The Detroit Lions will play their first game on the road for the 2026 season tonight against the Buffalo Bills at Highmark Stadium. Looking to watch the game from home? We’ve got all the information you’ll need to be ready for kickoff.

The Bills have elevated RB Frank Gore Jr. and WR Greg Dortch from the practice squad for tonight's game against the Lions. Gore is likely a one-for-one replacement for third-down running back Ty Johnson, who was limited at practice all week with a hamstring injury. Johnson has been dealing with the injury for over a month.

The Bills host the Lions on Thursday Night Football in Week 2.