The Detroit Lions lost defensive back Avonte Maddox early on Thursday night to injury at the Buffalo Bills.

Buffalo Bills wide receiver Keon Coleman briefly left Thursday's game against the Detroit Lions with an injury but returned two plays later.

Bills WR D.J. Moore appeared to suffer a shoulder injury in the first half against the Lions

Moore was hurt on a play with the Bills in the end zone, tangling with a Lions defender on the ground and remaining down on the turf in apparent pain. Moore was taken to the locker room for X-rays, leading one injury analyst to suggest he could face a dire outlook.

The Lions are already dealing with some major offensive line issues. Here's who they'll have to lean on on Thursday night.

A four-time Pro Bowler and the NFL's 2024 MVP, Allen opened 2026 by passing for 334 yards and a pair of touchdowns in the Bills ' 36-31 road win at the Houston Texans. Meanwhile, the Lions ' secondary surrendered 410 passing yards and three touchdowns to New Orleans Saints quarterback Tyler Shough in Week 1.

Buffalo Bills wide receiver DJ Moore suffered a frightening injury against the Detroit Lions. Moore was hurt on a play at the goal line late in the second quarter, appearing to fall hard on his shoulder.

The Detroit Lions don’t have much time to enjoy their dramatic 31-30 overtime victory over the Buffalo Bills in Week 1 of the NFL season, as they immediately began preparations for a Thursday night matchup against the Buffalo Bills in Week 2.