Are we about to see a record-setting performance from Puka Nacua? Will Deebo Samuel hit the touchdown trifecta? Which rookie is poised for a true breakout game? Our analysts provide bold predictions for Week 6 of the 2025 NFL season.

SportsLine's Data Science team, AI Predictions and AI Ratings are generated for each player prop for NFL Week 6

The Jags lead the league in turnover differential at plus-8, and have an NFL-best 10 interceptions to go with four fumbles recovered. Crucially, they have scored six touchdowns and two field goals off those takeaways, and two others ended an opponent’s final drive in one-score games.

We're a third of the way through the NFL season and my survivor picks remain perfect after the Packers beat the Bengals in Joe Flacco's Week 6 debut. As we move into Week 7, confidence is sky high but options of good teams and great matchups are beginning to run low.

Denver does a phenomenal job as garnering pressure and containing the run game. Breece Hall, Saquon Barkley, and Chase Brown have a combined for 139 rushing yards in the last three games against the Broncos, plus Denver has 18 sacks in that span!

The Underdog promo code NEWSWEEK provides new daily fantasy players with a no-brainer offer for NFL Week 6 and more. Sign up for a new account here and make a $5 pick for big Week 6 games like Seahawks-Jaguars, 49ers-Buccaneers and Lions-Chiefs to instantly lock in $100 in bonus funds.