SportsLine's model has simulated every game 10,000 times and locked in its Week 2 NFL score predictions

The Cowboys defense was terrible in the season opener.

The Pittsburgh Steelers were dealt a tough Week 2 development, as the New England Patriots got an explosive weapon back at practice.

Home underdogs always elicit interest with NFL picks, and there's a bevy of them to choose from with your Week 2 NFL picks. The Jets are 4.5-point underdogs as they'll host the Packers, while the Cardinals have that same number as they welcome Seattle to town.

Mike Florio previews the Packers taking to MetLife for a key Week 2 tilt against the Jets, where Green Bay is staring down its longest losing streak since 1990-91 and New York will look for its first INT in 18 games.

He appeared in six games for the Jets last season and now has another opportunity to contribute to the defense. The move comes as the Jets continue adjusting their secondary after losing safety Minkah Fitzpatrick to a groin injury in the season opener.

A loaded Week 2 NFL schedule kicks off on Thursday Night Football when the Buffalo Bills host the Detroit Lions, with kickoff scheduled for 8:15 p.m. ET. NFL prediction markets are ramping into high gear with a star-studded showdown on tap for football fans.

Coming off an offensive explosion to begin the season, Caleb Williams and the Bears host the Vikings in Week 2, where Minnesota will look to overcome quarterback issues.