The Tampa Bay Buccaneers return home to face off against the San Francisco 49ers in Week 6. The 49ers got a positive injury update on Brock Purdy on Thursday mo

All of this went down a week after the Giants embarrassed themselves in a 26-14 defeat at the previously winless New Orleans Saints in Week 5. Given the unthinkable kicked off Week 6 in the NFL, pretty much anything could happen in the rest of this week's action.

In Week 5 of the 2025 NFL season, how many underdogs came out on top? Below, we provide a full list of the teams that pulled off an upset last week.

But Dart wasn't the only rookie to show out on Thursday. Cam Skattebo, the Giants' fourth-round pick out of Arizona State, rushed for 98 yards and three touchdowns in the win. Giants fans hyped the rookie duo after the massive win.

Kansas City is in a bad way and letting fringe playoff teams take it down, as shown by its Monday night loss to the Jaguars. The Chiefs' lone two wins this season came against the Giants and a banged-up Baltimore Ravens team that was missing Lamar Jackson for a chunk of the second half.

New York Giants rookie QB Jaxson Dart etched his name in the NFL history books during a stunning upset of the Philadelphia Eagles in Week 6.

Drake Maye, Stefon Diggs, and the New England Patriots put the rest of the NFL on alert Sunday night with an upset win over the Bills in Buffalo.

After falling down draft boards with a 0-4 start, Nico Iamaleava and UCLA pulled off an upset of a magnitude that hasn't occurred in 40 years.

Trevor Lawrence and the Jacksonville Jaguars pulled off one of the biggest upsets of the 2025 NFL season on Monday night over the Kansas City Chiefs.