Analysts forecast a defensive bloodbath as Nick Bosa eyes a struggling Miami frontline, while San Francisco’s high-octane offense looks to exploit an inexperienced secondary for a dominant victory.

Few think the Dolphins will win this game — they start the week as almost 2 touchdown underdogs. But Miami should be able to shore up some things that went wrong in their loss at the Raiders.

San Francisco 49ers vs Miami Dolphins odds for NFL Week 2 game betting, including point spread, moneyline, over/under for Sunday, Sept. 20, 2026.