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NFL Week 2 picks straight up, against spread

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· 2h

Prisco's Week 2 NFL picks: Rams rout Giants; Chargers, Patriots, Cowboys bounce back

It was a good start to the season for me with my NFL picks as I was above .500 both straight up and against the spread.

· 16h · on MSN

NFL Week 2 picks straight up, against the spread: Do Lions spoil Bills' stadium opener?

· 17h

NFL picks against the spread for Week 2 from our expert staff

· 6h

Watch Buffalo Bills vs Detroit Lions NFL game LIVE: Online stream, TV channels, and kick-off time

The Buffalo Bills host the Detroit Lions at Highmark Stadium (Orchard Park, New York) during Week 2 of the NFL regular season, on Thursday, September 17.

· 9h

What channel is Bills-Lions Thursday Night Football game on tonight live?

· 9h

Lions vs. Bills score, live updates: Josh Allen’s passing TD extends Buffalo lead to 14-0

· 9h

Josh Allen scores 5 TDs to open new Buffalo stadium. Bills vs. Lions score, highlights, stats

Allen completed a big third-and-7 pass to Keon Coleman early and then he threw a quick pass to Khalil Shakir who turned it into a 16-yard gain.

· 9h

Novig Promo Code GOAL100: Get $25 in Bonuses for Lions vs Bills & NFL Prediction Markets, TNF

· 10h

Thursday Night Football live updates: Bills vs Lions start time, TV channel tonight

NFL Week 2 picks: Our experts face off on Giants at Rams, Bengals vs. Texans and more

They say Week 1 is a liar, so who lied in their season opener? Bo Nix and the Denver Broncos looked like one of the worst teams in the NFL, we watched Drake Maye and Jordan Love lose to backup quarterbacks,

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2026 NFL Week 2 Picks: Best Bets For Every Game — Will's Wagers

Could we have hoped for a more invigorating Week 1? Here's hoping Week 2 is better — but if not, at least just as good. Let's check out my best bets for every Week 2 contest. This page may contain affiliate links to legal sports betting partners.

17hon MSN

NFL Week 2 predictions, picks, win probabilities for games this week

NFL Week 2 picks, predictions, win probabilities for Panthers vs Falcons, Saints vs Ravens, Vikings vs Bears, Packers vs Jets, Colts vs Chiefs, more.

15hon MSN

2026 week 2 NFL score predictions, best picks today: Expert reveals exact scores for every NFL game

SportsLine expert Eric Cohen reveals his score predictions for every game on the Week 2 NFL schedule

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NFL survivor picks, strategy: Week 2 safe, value, and trap options

David Fucillo provides NFL Survivor pool tips in Week 2, offering up safe, value, and trap picks.

Week 2 NFL Picks: Vikings Duel High-Powered Bears Offense

At the risk of falling into classic Week 1 overreactions, the Chargers somehow looked outmatched by an Arizona Cardinals team that lost 14 of its final 15 games last year. The Raiders also looked pretty good and could be getting their dynamic tight end Brock Bowers back in the lineup. Las Vegas not only covers but gets a win here.

Week 2 NFL betting guide, props, spreads: Model, expert, parlay, DFS and season-long fantasy picks unveiled

SportsLine's model enters Week 2 of the 2026 NFL season on a 53-39 run on top-rated picks dating back to 2024. One of its favorite picks at the best betting apps is the Buccaneers (-8.5, 40.5) covering versus Cleveland, which cashes well over 50% of the time. You can find the model's picks for every NFL Week 2 game here .