After a week of upsets and scares, NFL Week 2 offers more challenges ahead. Complicating matters are several divisional matchups between rivals, including Panthers vs. Falcons (+2.5), Vikings vs. Bears (-5.

Will Josh Allen and the Bills open their new stadium in style tonight against the Jahmyr Gibbs-led Lions? Can the Texans and Broncos bounce back from uncharacteristic performances in Week 1? Check out the Week 2 game picks!

Pittsburgh Steelers vs New England Patriots picks, predictions, odds, win probabilities for NFL Week 2 Sunday game Sept. 20, 2026. Who will win game?

New York Jets vs Green Bay Packers odds for NFL Week 2 game betting, including point spread, moneyline, over/under, total for Sunday, Sept. 20, 2026.