An essential cellular enzyme successfully transcribed synthetic DNA letters, bringing expanded genetic codes closer to biological use.

RNA drugs are the next frontier of medicine, but manufacturing them requires an expensive and labor-intensive process that limits production and produces metric tons of toxic chemical waste.

A vascular dilatation in the aorta can be life-threatening if it bursts. These so-called aortic aneurysms typically form in the same sites of the large blood vessel: either on the upper arch or in the ...

In this method, the nucleotide precursors are first converted into NTPs, which are then immediately used to produce mRNA. This technique eliminates the need for complex, multi-step reaction pipelines, ...

Nanopore direct RNA sequencing has long been promoted as the technology that will finally let biologists read RNA molecules exactly as they exist inside cells, chemical decorations and all. A ...

In living organisms today, complex molecules like RNA and DNA are constructed with the help of enzymes. So how did these molecules form before life (and enzymes) existed? Why did some molecules end up ...

Explore The RNA World and the 'sweet spot' for life's earliest beginnings on Earth. Discover how RNA catalyzed life and the precise conditions that allowed ...

Oceans churned with lava. Air filled thick with smoke. Asteroids stormed down incessantly. Life during the Hadean Eon four billion years ago was a struggle, and yet that was when it began. 1,2 With no ...

Deep inside every cell, messenger RNA molecules carry chemical decorations that were long dismissed as molecular noise. The ...

A team of Rice University bioengineers has developed a new way to create highly realistic "mock" patient samples that could help accelerate the development of faster, more accessible cervical cancer ...