The zona pellucida (ZP), a highly conserved extracellular matrix (ECM) enveloping mammalian oocytes, zygotes, and preimplantation embryos, is synthesized and dynamically remodeled by the oocyte during ...

One of the major age-related declines in female reproductive function is the reduced quantity and quality of oocytes. Here we demonstrate that structural changes in the zona pellucida (ZP) were ...

Researchers from Japan and France have successfully reconstituted the development of mouse egg cells, known as oocytes, from embryonic stem cells entirely in vitro, without the need for ovarian ...

(a) Fluorescence images showing the chromatin in FGO stained with DAPI. Scale bar, 20 μm. Yellow triangles indicate DAPI-dense heterochromatin foci and the red triangles denote the nucleoli or NLBs.

One characteristic of oocyte development and physiology that has been a mystery for 60 years is the highly present cytoplasmic lattices within the cytoplasm of mammalian oocytes. These were initially ...

The new method offers researchers a powerful new platform to investigate the molecular mechanisms that control oogenesis, the process by which egg cells develop, and lays important groundwork for ...