Cancer metastasis is a crucial area in cancer research that directly affects patient survival and treatment outcomes. Cancer cells often undergo adaptive metabolic changes during metastasis from in ...

Scientists led by a team at the Medical Research Council (MRC) Mitochondrial Biology Unit, University of Cambridge, have worked out how a molecular machine found in mitochondria—the “powerhouses” of ...

Failure to import pyruvate into the mitochondria of cardiomyocytes results in metabolic maladaptation, cardiac hypertrophy and heart failure, thus underscoring the central role of pyruvate metabolism ...

Monocarboxylate transporters (MCTs) are integral membrane proteins that mediate proton-coupled shuttling of small metabolites such as lactate, pyruvate and short-chain fatty acids across cellular ...

Investigators at KU Leuven have discovered that although mTOR signaling was important in primary breast tumors and lung metastases alike, the signals that activated mTOR were different between the two ...