Rams, 49ers and Picks
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With the season upon us, it's the perfect time to predict the Rams' final record by going through each game and picking L.A. to either win or lose. On paper, the Rams look like a team that could run the table, but that's much easier said than done.
Los Angeles Rams vs San Francisco 49ers odds for NFL Week 1 game betting, including point spread, moneyline, over/under for Thursday, Sept. 10, 2026.
If the Rams can triumph in their season opener against the 49ers on Thursday in Melbourne, they could cruise until a tough midseason stretch.
In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.