Panthers quarterback Bryce Young threw for a franchise-record 448 yards in an overtime win over Atlanta, while the 49ers signal-caller Brock Purdy, in his return from injury, tossed three scores as the team put up a season-high 41 points.

Bryce Young and the Carolina Panthers are in San Francisco facing Brock Purdy, Christian McCaffrey and the 49ers on “Monday Night Football.” Follow our writers for news, updates and analysis on tonight's game.

Panthers vs. 49ers, both eyeing a vital playoff victory. Check out game lines and key stats. Which team will come out victorious?

Keep it here for the latest live updates, scores and highlights from this must-see Monday nighter . . . Panthers vs. 49ers will broadcast nationally on ESPN/ABC in Week 12 of the 2025 season. Joe Buck (play-by-play commentator),

The San Francisco 49ers picked up a huge win in the NFC wild-card race on Monday night over the Carolina Panthers.

If the Panthers want to come out victorious in their first prime-time showcase since 2023, they'll have to go through an old friend to do it.