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Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to ...
Drug Target Review

Logic-gated DARPins show targeted T-cell activation in tumours

Learn how Logic-gated DARPins work to activate T cells selectively in solid tumours, enhancing therapeutic outcomes.
Healio

Rosnilimab achieves T-cell depletion, ‘clinical proof of concept’ in rheumatoid arthritis

CHICAGO — Rosnilimab, a novel pathogenic T-cell depleting drug, met its primary endpoint of changes in DAS28 C-reactive ...
EurekAlert!

JMC Publication: Insilico’s AI platforms enable discovery of potent, selective, oral DGKα inhibitor to overcome checkpoint resistance

Novel, Potent, Selective and Orally Available DGKα Inhibitors for the Treatment of Tumors view more . Credit: Insilico ...
European Medical Journal

New Dual-Target T-Cell Design Boosts Attack on Solid Tumours

Researchers have developed a new strategy that allows engineered T cells to recognize and respond to a single tumour antigen ...
News-Medical.Net on MSN

Poor dietary iron weakens lung memory T cells after flu infection

Dietary iron deficiency in mice alters lung T cell activation during influenza infection and leads to memory T cells that are ...
MarketWatch

Aptevo Debuts First Trispecific Antibody Candidate, APVO451, with Preclinical Data Demonstrating Immune Activation in Hard-to-Treat Solid Tumors

The MarketWatch News Department was not involved in the creation of this content. First data on Aptevo's new molecule presented at the Society for Immunotherapy of Cancer (SITC) Annual Meeting SEATTLE ...
BioWorld

STK-012 boosts T-cell activation while minimizing side effects

Researchers from Synthekine Inc. presented preclinical efficacy data on STK-012, a first-in-class IL-2 partial agonist engineered for preferential binding to the IL-2Rαβγ receptor.