Bioengineers can tailor the genomes of cells to create "cellular therapies" that fight disease, but they have found it difficult to design specialized activating proteins called transcription factors ...

Transcription factors do not contain such structures, and so standard searches for RNA binding domains had not identified them in transcription factors. Young, Oksuz and Henninger got their biggest ...

A new review in Molecular Cancer details how the TEAD family of transcription factors drives cancer, the drugs now targeting ...

New research has uncovered more about the complexity of human gene regulation by identifying certain sequences of proteins called transcription factors that bind to DNA and regulate the expression of ...

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, according to a recent study published in ...

Scientists studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA. Like thread tightly wrapped around a spool, DNA is wrapped around ...

New research shows that the transcription factor C/EBPβ normally restrains an inflammatory interferon and TNF-α program that, ...

Barley (Hordeum vulgareL.), a crucial cereal crop known for its resilience to harsh environmental conditions, relies on complex genetic networks to withstand abiotic stressors such as drought, ...

Transcription Factors (TFs) are pivotal regulators of gene expression and have been implicated in a variety of diseases, including cancer, neurological disorders, autoimmune conditions, and metabolic ...

This image illustrates the process of gene transcription within a cell. The DNA double helix unwinds to expose a specific sequence, allowing RNA polymerase to synthesize a complementary pre-mRNA ...

Bioengineers have developed a generalizable method to address 'off-target' binding, a significant problem in the field of synthetic biology. Taking a cue from nature, the researchers showed they could ...