Now, SportsLine's NFL DFS Optimizer has turned its attention to Sunday's 2025 NFL Week 6 schedule and just locked in its top daily Fantasy football lineups. You can only see its optimal lineups at SportsLine.

We sort Sunday's games by walk-off potential. The 49ers and Bucs have made nail-biters their norms, while Lions vs. Chiefs screams "drama."

NFL DFS Week 6 cash game picks for DraftKings and FanDuel. Build safe, high-floor lineups with Kelly Singh's favorite plays for Sunday’s main slate games.

Keep up with the 2025 NFL season on FOX Sports. Prior to the final injury report, which lists players as questionable, doubtful or out, NFL teams use practice designations to update player injury statuses. This can include DNP (did not participate), LP (limited participant) or FP (full participant).

Here are the best arrivals pregame looks from Week 6. Philadelphia Eagles wide receiver DeVonta Smith made a statement ahead of "Thursday Night Football" against the New York Giants with a gold-glaring silk suit.

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This week's NFL on FOX slate features a few intriguing matchups between teams either looking to prove they're for real or trying to right the ship.

The Colts have played one down-to-the-wire game, which they won. The Cardinals have played three straight nail-biters, and they haven't gone well.