This valuable study substantially improves the phylogenetic framework for Kinetoplastea through greatly expanded sampling of free-living neobodonids; the phylogenomic analyses provide convincing ...

Biochemical and electrophysiological approaches show that the amphetamine derivative ECSI#6 is an uncompetitive inhibitor of the serotonin transporter and thus the first ever characterized ligand of a ...

eLife reviews research into cancer spanning from oncogenes and tumor suppressors to metastasis and anticancer treatments. Learn more about what we review and sign up for the latest research.

A family of proteins called Toll receptors, best known for their role in the immune system, also enable the brain to change its structure in response to experience. Everything that you experience ...

Add a comment + Open annotations. The current annotation count on this page is being calculated. People with certain blood types are more likely to have blood clots or bleeding conditions, kidney ...

New funding, awards for metadata and UX excellence, and outstanding research articles are among the highlights of the past year at eLife. Last week, Wellcome announced a £2.4m investment in eLife ...

A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the ...

Crystal structures of γ-protocadherin cell-cell recognition dimers reveal the determinants of clustered protocadherin homophilic specificity and cis interaction region structures alongside mutagenesis ...

Cryo-EM structures of 70S•RelA ribosome complexes reveal how cognate deacyl-tRNA activates RelA.

This study examines an interplay between synaptic mitochondria and glutamate receptor exocytosis in C. elegans. Collectively, the solid results support the idea that mitochondrial function influences ...

where ΔG (γ = 0) is the free energy difference at zero tension, γ the membrane tension and ΔA the in-plane cross sectional area change associated with channel opening (Haswell et al., 2011). Thus, ...

To control reaching, the nervous system must generate large changes in muscle activation to drive the limb toward the target, and must also make smaller adjustments for precise and accurate behavior.