Background SLE is a complex autoimmune condition requiring evaluation across disease activity, permanent damage and ...

Objective Systemic lupus erythematosus Prospective Observational Cohort Study (SPOCS) was a prospective observational study ...

Objective Corticosteroids are a mainstay of SLE treatment; however, cumulative steroid exposure may lead to organ damage. This study aimed to quantify the risk of new diabetes, hypertension, cataracts ...

Objective Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterised by venous thrombosis (VT) or arterial thrombosis (AT) and/or pregnancy morbidity and the presence of ...

Objective Epidemiological studies have shown that discoid lupus erythematosus (DLE) has a higher incidence and prevalence in racial/ethnic minority groups, particularly Black individuals. The ...

Objectives Genetic variation within the human leukocyte antigen (HLA) region influences susceptibility across systemic autoimmune diseases (SADs). We investigated HLA class I and II allelic ...

Introduction Lupus nephritis (LN) is a frequent complication of SLE, occurring in up to 60% of adult patients and ultimately progressing from acute inflammation to chronicity with fibrosis and ...

Objective This study explored the relationship between clinical phenotypes and immuno-molecular features of systemic lupus erythematosus (SLE) using unsupervised machine learning and multi-omics ...

Purpose This study investigated the topological structural characteristics of systemic lupus erythematosus (SLE) with and without neuropsychiatric symptoms (NPSLE and non-NPSLE), and explore their ...

Patients with immune-mediated inflammatory diseases (IMIDs) are at increased risk of herpes zoster (HZ), particularly those with SLE, in whom HZ may be more frequent and severe.1 Recombinant zoster ...

Objective To characterise the safety and efficacy of anifrolumab in active lupus nephritis (LN) through year 2 of the phase II randomised, double-blind Treatment of Uncontrolled Lupus via the ...