Drug Discovery & Development

Merck and Moderna’s cancer vaccine is customized for each patient’s tumor

A new investigational cancer vaccine developed by Merck & Co. and Moderna is customized based on the genome of each patient's ...
Drug Discovery & Development

The oral exposure challenge in PROTACs: What drug developers need to solve early

A WuXi AppTec director examines strategies for improving oral PROTAC exposure, from food-effect studies and linker design to ...
Drug Discovery & Development

AbbVie’s Maviret cured 96% of HCV trial participants. The real world is more complicated.

AbbVie's MAVYRET became the first of those antivirals cleared for acute infection in June 2025, with a 96% cure rate in trial ...
Drug Discovery & Development

As the dream of the autonomous clinical trial dawns, agent supervision is today’s human job

Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug ...
Drug Discovery & Development

Tufts model estimates 82x ROI and up to $21 million in value from Medable AI agent

Medable’s Pamela Tenaerts says “the CRA still needs to be there,” as she and Tufts’ Ken Getz explain how agents change ...
Drug Discovery & Development

FDA greenlights ViiV’s Tivicay PD for HIV-positive newborns in first month of life

The FDA has approved ViiV Healthcare’s Tivicay PD (dolutegravir) for treating HIV-1 in pediatric patients weighing at least 2 ...
Drug Discovery & Development

FDA logs more than 1,700 adverse event reports involving compounded semaglutide and tirzepatide

FDA has logged more than 1,700 adverse event reports involving compounded semaglutide and tirzepatide as regulators, ...
drugdiscoverytrends

FDA issues final PDUFA meeting guidance, expands use of written responses

The FDA has finalized new guidelines for meetings between the FDA and sponsors or applicants relating to the development and review of drugs or biological products under the Prescription Drug User Fee ...
Drug Discovery & Development

Before its recent Phase 3 LSD win, Definium modeled up to $70,000 a year for a therapy that could fill a clinical shift

Drug Discovery and Development covers strategies and technologies related to pharmaceutical research and development and drug formulation.
drugdiscoverytrends

Brian Buntz

The GLP-1 wave keeps widening Semaglutide hits the GLP-1 receptor alone, tirzepatide adds a second in GIP, and next-generation candidates layer on a third in glucagon or drop incretins altogether for ...
drugdiscoverytrends

Drug Discovery

As of early February, TrumpRx.gov displays only a stylized Oval Office portrait of the president and the words “Coming Soon.”In early 2025, Donald Trump Jr. joined the board of BlinkRx, a digital ...