The Cowboys have a new-look defense with new defensive coordinator Christian Parker and first-round pick Caleb Downs. The John Harbaugh era begins in New York. Dak Prescott is 14-3 S/U against the Giants – and Dallas has won nine of the last 10 meetings.

Sam Darnold and the Seattle Seahawks will see their championship banner raised before hosting Drake Maye and the New England Patriots in a Super Bowl rematch to kick off the NFL season on Wednesday ni

In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.