Winfrey is reflecting on how a leap of faith changed her career and her life forever ...

'Oprah had nothing prepared for the audition that changed her life...' ...

Whoopi Goldberg announced the stunning moment on air, which made some audience members double over as they cried.

Oprah Winfrey shows off her dramatic 82Lbs transformation at 72, with her slimmed-down waist and glamorous look.

Driving the news: Tuesday marks the 40th anniversary of the first national broadcast of "The Oprah Winfrey Show" from Chicago ...

The Oprah Winfrey Show debuted 40 years ago, forever altering the daytime talk landscape in its wake. But we bet you don't know these fascinating facts about the billionaire who started it all.

The show that launched Oprah Winfrey to stardom was born and produced in Chicago, and broadcast to viewers across the country ...

Beauty pageants can be an excellent training ground for future stars. Oprah, Michelle Pfeiffer, and Priyanka Chopra Jonas are ...