Since the technique was first published in 2019, prime editing has grown with lightning speed, alongside hopes for what it can achieve. Emilie is an assistant editor at the Scientist. She has a ...

Continue reading about off-target effects in this story. Base and Prime Editing Offer Precision CRISPR-based systems that rely on traditional Cas nucleases like Cas9 cut through both strands of DNA ...

The prime editor is a fusion protein consisting of a catalytically impaired Cas9 nickase (Cas9n) and an engineered reverse transcriptase (RT). The Cas9n is guided by a prime editing guide RNA (pegRNA) ...

The new method uses a combination of prime editing, which can directly make a wide range of edits up to about 100 or 200 base pairs, and newly developed recombinase enzymes that efficiently insert ...

Prime Medicine has been given the go-ahead by the FDA for the first human trial of its prime editing technology, which promises to deliver one-shot therapies for a range of severe genetic diseases.

In 2023, a research team from St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed proof-of-concept for prime editing in animal models of sickle cell disease.

Under the terms of the agreement, Prime Medicine will design optimized Prime Editor reagents for a select number of targets, including reagents that use its Prime Assisted Site-Specific Integrase ...

Here, authors apply prime editing (PE) system to correct the point mutation in a preclinical RP mouse model. In vivo treatment achieves genome editing and restores mice vision. Exploration of ...

Stock analysts at HC Wainwright boosted their Q1 2025 earnings per share (EPS) estimates for shares of Prime Medicine in a ...