Joe Osborn offers his early 49ers vs. Rams predictions ahead of Thursday Night Football in Melbourne, Australia. Free NFL picks for September 10.

See our experts' final 49ers-Rams NFL Week 1 predictions for Thursday's matchup, with Christian McCaffrey listed among the best available player props.

With the season upon us, it's the perfect time to predict the Rams' final record by going through each game and picking L.A. to either win or lose. On paper, the Rams look like a team that could run the table, but that's much easier said than done.

If the Rams can triumph in their season opener against the 49ers on Thursday in Melbourne, they could cruise until a tough midseason stretch.

In Sporting News' first picks and predictions against the spread for the 2026 NFL regular season, the Seahawks and Rams get off to great starts as co-favorites in the NFC West, while the Giants and Eagles win in their opening NFC East matchups.

Rams vs. Chiefs Prediction: How Much Time Will Rookie Ty Simpson Get in Preseason Debut? Kansas City is a 2.5-point home favorite, with the Chiefs -2.5 (-110), Los Angeles +2.5 (-110) and the total at 36.5. The Rams went 12-5 last season and reached the ...

Rams ready to make a statement. The Rams come into this one with all the hype. On offense, this was the number one-ranked unit in the NFL last season and brought back every starte