How membraneless organelles assemble into organized protein hubs

Inside every cell, thousands of proteins must reach the right place at the right time. Helping coordinate this complex ...
Science

RNA delivery to the corneal endothelium using charge-altering releasable transporters

RNA therapies hold tremendous promise for treating genetic eye diseases. However, their development is limited by the lack of ...
Science

Structural basis for target discrimination and activation by Cas13d

CRISPR-Cas13d is increasingly used for RNA knockdowns, but off-target cleavage of near-cognate RNAs hinders its broader ...
eLife

Local inhibitory dynamics underpin temporal integration and functional segregation between barrels and septa in the mouse barrel cortex

Argunşah et al. investigate the mechanisms underlying the differential response dynamics of barrel vs septa domains in shaping the responses to single vs multiple whiskers. Based on the observation of ...