Less than one week remains until the Arizona Cardinals open up the 2026 regular season.Arizona is taking on the Los Angeles Chargers in the first of a string of games in which the odds are stacking against them.

Arizona Cardinals head coach Mike LaFleur gave one important injury update on Monday, expressing optimism that rookie running back Jeremiyah Love will be able to play on Sunday in the season opener against the Los Angeles Chargers. However, he was mum about the injury status of another key player.

As such, there is no surprise that the Cardinals are big underdogs. In fact, they are the biggest underdogs of the week, per BetMGM Sportsbook. While the spread opened at -10 for the Chargers, it has since shifted.