Los Angeles Chargers DB Deane Leonard (abdomen) and LB Khalil Mack (rest) did not participate in practice Wednesday, Sept. 9.

He’s just been very good, very consistently good,” Coach Jim Harbaugh says of the former Detroit Lions offensive lineman, who ...

USA TODAY Sports' Tyler Dragon examines the winners and losers from Thursday night's preseason game between the 49ers and Chargers.

Expert Jeff Hochman has revealed his Los Angeles Chargers vs. San Francisco 49ers picks for the 2026 NFL preseason Week 2 Thursday matchup ...

The 49ers after three quarters have controlled much of the contest. They've dominated through 45 minutes. The 49ers outgained the Chargers in offensive yards, 284 to 156. San Francisco has 18 first ...

Our 49ers vs. Chargers prediction for Thursday's NFL preseason matchup expects Los Angeles to have the advantage at home once both teams pull their starters.

The San Francisco 49ers crushed the Los Angeles Chargers in a preseason matchup at SoFi Stadium. We have the highlights.

There was plenty to learn from the San Francisco 49ers' blowout win over the Los Angeles Chargers in Week 2 of the preseason.

EL SEGUNDO, Calif. (AP) — Los Angeles Chargers center Tyler Biadasz was carted off the field with a left leg injury during Tuesday’s joint practice with the San Francisco 49ers. Biadasz went down ...

The San Francisco 49ers beat the Los Angeles Chargers on Thursday at SoFi Stadium. These players had great nights for Kyle ...

San Francisco 49ers quarterback Brock Purdy throws the ball against the Los Angeles Chargers in the first half of an NFL preseason game Thursday at SoFi Stadium in Inglewood. Kirby Lee IMAGN IMAGES ...

Expert recap and game analysis of the San Francisco 49ers vs. Los Angeles Chargers NFL game from August 20, 2026 on ESPN.