Week 1 NFL Point Spreads

Betting picks against spread for Week 1 prime-time games

NFL Week 1 odds, point spreads, moneylines, over/unders for games

NFL Week 1 betting spreads, lines, point totals for every game on the NFL Week 1 schedule, with odds for favorites and underdogs in each NFL matchup.

Cards Wire · 12h

NFL best bets: Betting picks against the spread for Week 1 early games

· 21h

NFL Week 1 betting primer: 13 games, trends and key numbers

· 12h

What NFL games are on today? Week 1 schedule, start times, TV channel

The 2026 NFL season is here, and it kicked off Wednesday night with a Super Bowl rematch.

· 6h

Best NFL Betting Promos for Week 1: Sportsbook Promos, Bonus Codes for Cowboys-Giants, Sunday Night Football

· 17h

What channels are NFL games on Sunday? How to watch NFL Week 1 on TV

· 7h

NFL Week 1: Takeaways, questions, fantasy spin for Sunday games

On Wednesday, the Seahawks defeated the Patriots again in a Super Bowl LX rematch -- this time without quarterback Sam Darnold.

· 8h

Week 1 NFL odds, picks, predictions: Computer model backs Eagles and Jaguars

· 9h

BetMGM Bonus Code SBWIREBG1K Scores $1000 Bonus for NFL Week 1 Today

Updated NFL Week 1 Odds With Point Spreads

We dive into the first week pro football odds and see if there has been any sort of line movement ahead of the start of the season.

10h

NFL Week 1 odds, predictions, expert picks: Who has edge in Packers-Vikings? Can Giants upset Cowboys?

Week 1 of the 2026 NFL season is officially here, and what better way to begin this season than by having football played on four different days? We had a Super Bowl rematch on Wednesday, Australia football on Thursday and then get a full slate to digest on Sunday,

SportsLine

Bills vs. Texans prediction, line, odds: Proven model releases spread pick for 2026 NFL Week 1 matchup

The SportsLine projection model, which is on a 53-37 run on top-rated picks dating back to 2024, reveals its Buffalo Bills vs. Houston Texans picks for Sept. 13

14h

Oddsmakers rank every NFL starting QBs by point-spread value: Josh Allen is the clear No. 1

For example, back in January when Denver Broncos QB Bo Nix was ruled out of the AFC championship game with a broken ankle suddenly (leaving Jarrett Stidham as the starter), the Broncos went from a lookahead line of Denver -1.5 to +4.5 against the New England Patriots (which was then quickly bet up to Denver +5.5).

NFL Week 1 odds, picks: Jags throttle Deshaun Watson-led Browns, plus two underdogs win outright

Last year was the perfect example of how unpredictable the league can be. Both Seattle and New England had +6000 odds at this time last year to win Super Bowl LX. To put that into perspective, that'd be like if either the Commanders or the Colts (both currently +6000) win Super Bowl LXI this February. Crazy!

4don MSN

NFL Week 1 picks: Rams prevail over 49ers; Broncos beat Chiefs

Sam Farmer makes his picks and score predictions for Week 1 of the 2026 season, with the Rams winning in Australia and the Chargers beating the Cardinals.

12hon MSN