Plants produce a wide diversity of compounds. Broadly, these are separated into primary metabolites, which are necessary for ...

Arthritis was induced in mice exposed to high blood levels of homocysteine. Hyper-homocysteinemia arthritic animals develop diastolic dysfunction (the left ventricle does not dilate properly) with ...

TP53 -mutant acute myeloid leukemia (AML) and myelodysplastic neoplasms (MDS) are characterized by chemotherapy resistance and represent an unmet clinical need. Chimeric antigen receptor (CAR) T-cells ...

Neural stem cells (NSCs) in the mammalian brain decline rapidly with age, leading to impairment of hippocampal memory function in later life. However, the relationship between epigenetic remodeling ...

We identified a heterozygous missense mutation in IL36RN (IL36RN S113L) in a therapy-refractory Crohn’s disease patient. Functional assays and overexpression experiments demonstrated that this ...

DNMT3A mutations may also have hitherto unrecognised non-canonical functions in HSCs. TP53 in humans, or Trp53 in mice (generally referred to as p53 throughout this text) is a key tumour suppressor ...

In this study, we provide a detailed molecular analysis of the KMN subunit Kre28 Zwint. We identified a conserved Zwint helix in Kre28 whose lack leads to fatal chromosome segregation defects when ...

The ER membrane protein SELENOT has been previously suggested to be neuroprotective, but its contribution to neuronal pathophysiology has not been thoroughly investigated. This study reports that ...

Diverse sets of progenitors contribute to the development of the embryonic heart, but the mechanisms of their specification have remained elusive. Here, using a human pluripotent stem cell (hPSC) ...

Corneal diseases can cause severe visual impairment and even blindness, which have been linked to the interruption of corneal epithelial homeostasis. However, the underlying molecular mechanisms are ...

The endoplasmic reticulum (ER) of the eukaryotic cell is the major site of lipid and membrane protein synthesis, and it acts as a hub for intracellular communication. This organelle extends from the ...

Alveolar type 2 (AT2) cells maintain lung health by acting as stem cells and producing pulmonary surfactant. AT2 dysfunction underlies many lung diseases, including interstitial lung disease (ILD), in ...